Inflammation, Tumoral Markers and Interleukin-17, -10, and -6 Profiles in Pancreatic Adenocarcinoma and Chronic Pancreat
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ORIGINAL ARTICLE
Inflammation, Tumoral Markers and Interleukin‑17, ‑10, and ‑6 Profiles in Pancreatic Adenocarcinoma and Chronic Pancreatitis Alina Tanţău1,2 · Daniel‑Corneliu Leucuţa3 · Marcel Tanţău4,5 · Emil Boţan6 · Roxana Zaharie4,5 · Alina Mândruţiu2 · Ionuţ‑Ciprian Tomuleasa7 Received: 15 April 2020 / Accepted: 27 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Interleukin profiles can be used as biochemical markers regarding the early diagnosis of pancreatic cancer. Aims To assess CRP, CA 19-9, CEA levels, and interleukin-6, -10, and -17 profiles in pancreatic ductal adenocarcinoma, chronic pancreatitis was compared with a control group, and the correlation with pancreatic cancer survival. Methods A total of 87 patients were prospective divided in pancreatic cancer (n = 53), chronic pancreatitis (n = 22) ,and control group (n = 12). The diagnosis of PDAC was made histologically. The diagnosis of chronic pancreatitis was based on medical history, imaging methods, and endoscopic ultrasound. Systemic concentrations of interleukins were measured using ELISA kits. The patients were followed at 1, 3, and 6 months. Results CRP, CA 19-9, and CEA were higher in the pancreatic cancer group (p
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