Inhalation Toxicology The Design and Interpretation of Inhalation St
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U. Mohr
Editor-in-Chief
Inhalation Toxicology The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment D. Dungworth G. Kimmerle 1. Lewkowski R. McClellan W. Stober
Editors
Springer-Verlag New York Berlin Heidelberg London Paris Tokyo
Ulrich Mohr, Dr. med. Professor of Experimental Pathology, Medizinische Hochschule Hannover, Institut fur Experimentelle Pathologie, Konstanty-Gutschow-StraBe 8,3000 Hannover 61, FRG
Donald L. Dungworth, Ph.D., M.R.C.V.S Department of Veterinary Pathology, University of California, Davis, CA 95616, USA
Georg Kimmerle, Dr. med. Bayer AG, Institute for Toxicology, 5600 Wuppertal-Elberfeld, FRG
James Lewkowski, M.D. Abbott Laboratories, Abbott Park, IL 60064, USA
Roger O. McClellan, D.v.M. Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, P.D. Box 5890, Albuquerque, NM 87185, USA
Werner Stober, Dr. rer.nat. Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Strasse 1, 3000 Hannover 61, FRG
Library of Congress Cataloging-in-Publication Data Inhalation toxicology : the design and interpretation of inhalation studies and their use in risk assessment / D. Dungworth . .. [et al.l ; U. Mohr, editor-in-chief. p. cm. - (ILSI monograph series) Bibliography: p. ISBN-13: 978-3-642-64806-9 DOl: 10.1007/978-3-642-61355-5
e-ISBN-13: 978-3-642-61355-5
1. Gases, Asphyxiating and poisonous-Toxicology. 2. Gases, Asphyxiating and poisonous-Physiological effect. 3. ToxicologyAnimal models. 4. Toxicity testing. I. Dungworth, D. L. (Donald Lawrence) II. Mohr, U. (Ulrich) III. Series. RA1245.155 1988 615.9'I-dc 19
© 1988 by Springer-Verlag New York Inc. Softcover reprint ofthe hardcover lst edition 1988 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer-Verlag, 175 Fifth Avenue, New York, NY 10010, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Typeset by Publishers Service, Bozeman, Montana.
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