Nanoparticles in medicine and environment Inhalation and health effe
A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these partic
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Nanoparticles in Medicine and Environment Inhalation and Health Efects
AB 3
Nanoparticles in Medicine and Environment
Jan C.M. Marijnissen
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Leon Gradon´
Editors
Nanoparticles in Medicine and Environment Inhalation and Health Effects
Editors Jan C.M. Marijnissen Delft University of Technology Dept. Chemical Engineering Julianalaan 136 2628 BL Delft Netherlands
Leon Gradoń Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warynskiego 1 00-645 Warsaw Poland
ISBN 978-90-481-2631-6 e-ISBN 978-90-481-2632-3 DOI 10.1007/978-90-481-2632-3 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009941459 # Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Cover design: Boekhorst Design Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Introduction
Currently a huge effort is put into nanoparticle research and the production of nanoparticles. In many cases it is unavoidable that during the production processes or during the use of the particles or a product made from these particles, nanoparticles are released into the environment. It is also realized that combustion processes, including traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit in and affect the human system. During May 30 and 31, 2008, a group of scientists met in the Jablonna Palace near Warsaw in Poland to discuss all aspects from the origin/production of the nanoparticles till the interaction with the lungs and the toxic/therapeutic effects. This workshop, the fourth in a series of very specialized workshops on aerosol particles and the human body, brought together top-experts from different disciplines but all in the field related to aerosol nanoparticle release/production and nanoparticles inhalation and the effects. The subjects were assembled in three main themes: Sources and Production, Inhalation and Deposition, Toxicological and Medical Consequences. The workshop was concluded with an overview and a roundtable discussion. The chapters in this book, including the last one, which reports the overview and discussions, make clear how complex the subject is and that it only can be attacked by an interdisciplinary approach. It also made evident that much is still unknow
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