Inorganic Polyphosphates in Eukaryotic Cells
The book elucidates the role of inorganic polyphosphates in eukaryotic cells, from fungi and protozoa to human being. To date, there is plenty of evidence that these anionic biopolymers occurring in the cells of all living organisms, from bacteria to huma
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ganic Polyphosphates in Eukaryotic Cells
Inorganic Polyphosphates in Eukaryotic Cells
Tatiana Kulakovskaya • Evgeny Pavlov Elena N. Dedkova Editors
Inorganic Polyphosphates in Eukaryotic Cells
Editors Tatiana Kulakovskaya Laboratory of Regulation of Biochemical Processes Skryabin Institute of Biochemistry and Physiology of Microorganisms Russian Academy of Sciences Pushchino, Russia
Elena N. Dedkova Department of Pharmacology University of California Davis, CA USA
Evgeny Pavlov NYU College of Dentistry New York, New York USA
ISBN 978-3-319-41071-5 ISBN 978-3-319-41073-9 DOI 10.1007/978-3-319-41073-9
(eBook)
Library of Congress Control Number: 2016957150 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland The registered company address is Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Inorganic polyphosphate is a biological polymer made of many orthophosphates linked together by phosphoanhydride bonds similar to ones found in ATP. polyP is a unique macromolecule that can spontaneously form in nonliving nature and can also be enzymatically produced by living organisms. Over the past few decades, a number of exciting hypotheses regarding the role of polyP in nature have been generated. These range from the concept that polyP can be a prebiotic molecule that was at the origin to living organisms to the concept that polyP can serve as a storage of biological fuel alternative to ATP. Despite its discovery over a century ago, the molecular mechanisms of polyP actions in living organisms remain poorly understood. In fact, most of current knowledge about biological roles of polyP comes from the studies of bacterial organisms and lower eukaryotes with very little studies of higher eukaryotes. One of the central unresolved questions in polyP research is about the relat
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