Insulin resistance and metabolic syndrome in normal-weight individuals
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ORIGINAL ARTICLE
Insulin resistance and metabolic syndrome in normal-weight individuals Shanying Chen • Youming Chen • Xinyu Liu • Mi Li • Bide Wu • Yongqiang Li • Yan Liang • Xiaofei Shao • Harry Holtho¨fer • Hequn Zou
Received: 31 July 2013 / Accepted: 4 October 2013 Ó Springer Science+Business Media New York 2013
Abstract We performed this study to investigate the prevalences of insulin resistance and metabolic syndrome (MetS) in a Chinese population with normal weight. We also examined whether fat mass is associated with insulin resistance and MetS in normal-weight individuals. Data were drawn from a cross-sectional study in China. Subjects with diabetes were excluded. The prevalences of insulin resistance and MetS were calculated. Multivariate logistic regression analysis was performed repeated separately for body mass index (BMI) and waist circumference (WC) in both men and women. We also used the combination of BMI and WC to predict insulin resistance and MetS. 8.55 % of normal-weight men and 12.62 % of normal-
Shanying Chen and Youming Chen have contributed equally to this study. S. Chen X. Liu Y. Li Y. Liang X. Shao H. Zou (&) Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, 183# Zhongshan Dadao, Tianhe District, Guangzhou 510000, People’s Republic of China e-mail: [email protected] S. Chen B. Wu Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, People’s Republic of China Y. Chen Clinical Laboratory, The Third Affiliated Hospital of Southern Medical University, Guangzhou, People’s Republic of China
weight women had insulin resistance. 7.41 % of normalweight men and 10.24 % of normal-weight women had MetS. WC was associated with incident insulin resistance and MetS independent of BMI in both men and women. BMI was independently associated with incident MetS in women. Normal-weight individuals with insulin resistance and/or MetS are not rare in the Chinese population. Fat mass is associated with insulin resistance and MetS in normal-weight subjects. The current findings support using both BMI and WC in clinical practice. Keywords Insulin resistance Metabolic syndrome Normal weight Abbreviations MetS Metabolic syndrome BMI Body mass index WC Waist circumference ATP III Third Report of the National Cholesterol Education Program’s Adult Treatment Panel CI Confidence interval HDL-C High-density lipoprotein-cholesterol HOMA Homeostasis model assessment OR Odds ratio CRP C-reactive protein eGFR Estimated glomerular filtration rate Scr Serum creatinine
M. Li Blood Purification Center, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China
Introduction
H. Holtho¨fer National Centre for Sensor Research/BioAnalytical Sciences, Dublin City University, Dublin, Ireland
Insulin resistance is a hallmark of metabolic syndrome (MetS) and largely initiated by obesity [1]. The existence of a subgroup of individuals with normal weight but with
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Endocrine
metabolic disturba
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