Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstru
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RESEARCH
Influence of multiple apolipoprotein A‑I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea Xinyi Li1,2,3†, Zhihui Fu1,2,3†, Huajun Xu1,2,3*, Jianyin Zou1,2,3, Huaming Zhu1,2,3, Zhiqiang Li4, Kaiming Su1,2,3, De Huai5*, Hongliang Yi1,2,3*, Jian Guan1,2,3 and Shankai Yin1,2,3
Abstract Background: The relationships between apolipoprotein A-I (APOA-I), apolipoprotein B (APOB) with insulin resistance, metabolic syndrome (MetS) are unclear in OSA. We aimed to evaluate whether the multiple single nucleotide polymorphism (SNP) variants of APOA-I and APOB exert a collaborative effect on insulin resistance and MetS in OSA. Methods: Initially, 12 APOA-I SNPs and 30 APOB SNPs in 5259 subjects were examined. After strict screening, four APOA-I SNPs and five APOB SNPs in 4007 participants were included. For each participant, the genetic risk score (GRS) was calculated based on the cumulative effect of multiple genetic variants of APOA-I and APOB. Logistic regression analyses were used to evaluate the relationships between APOA-I/APOB genetic polymorphisms, insulin resistance, and MetS in OSA. Results: Serum APOB levels increased the risk of insulin resistance and MetS adjusting for age, gender and BMI [odds ratio (OR = 3.168, P
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