Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosph
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ORIGINAL ARTICLE
Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate‑resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels Christina Patlaka1 · Bojan Tubic2 · Pernilla Lång1 · Staffan Paulie3 · Diana Swolin‑Eide4,5 · Per Magnusson6 · Göran Andersson1 Received: 30 April 2019 / Accepted: 3 September 2019 © The Author(s) 2019
Abstract Aim Tartrate-resistant acid phosphatase (TRAP) exists as isoforms 5a and 5b. TRAP 5a is a biomarker of chronic inflammation and influences adipose tissue and 5b associates with bone metabolism/pathologies. The aim was to investigate the association of serum TRAP 5a/5b isoforms with fat and bone markers and anthropometric parameters in patients with anorexia nervosa (AN) during weight gain therapy. Methods Twenty-five Swedish female AN patients, age 16–24 years, were treated for 12 weeks with a high-energy diet with six meals daily. Serum TRAP 5a/5b, markers of fat/glucose metabolism, markers of bone resorption and formation were measured. Parameters of bone and body composition were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Results BMI increased from median 15.4 kg/m2 to 19.0 kg/m2, p
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