Interaction of Mycophenolic Acid and Pantoprazole A Pharmacokine
Olesja Rissling analyzes the potential interaction of mycophenolic acid (MPA) and pantoprazole. MPA is used as an immunosuppressive drug to prevent acute organ rejections after organ transplantation. Pantoprazole, known to interact with the bioavailabilit
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Interaction of Mycophenolic Acid and Pantoprazole A Pharmacokinetic Crossover Study
Interaction of Mycophenolic Acid and Pantoprazole
Olesja Rissling
Interaction of Mycophenolic Acid and Pantoprazole A Pharmacokinetic Crossover Study
Olesja Rissling Berlin, Germany Dissertation Freie Universität Berlin, Germany, 2017 D188
ISBN 978-3-658-19888-6 ISBN 978-3-658-19889-3 (eBook) https://doi.org/10.1007/978-3-658-19889-3 Library of Congress Control Number: 2017955535 Springer Spektrum © Springer Fachmedien Wiesbaden GmbH 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer Spektrum imprint is published by Springer Nature The registered company is Springer Fachmedien Wiesbaden GmbH The registered company address is: Abraham-Lincoln-Str. 46, 65189 Wiesbaden, Germany
Acknowledgements
First, I would like to express my deepest appreciation to my supervisor Professor Budde for the opportunity to do my PhD work in his research group and for his immense support, advice and the valuable discussions. Also, I am thankful for the research and learning opportunities he offered to me. I wish to express my sincere thanks to Professor Melzig for accepting me as an external PhD student at the Institute of Pharmacy and for his continuous and great support and advice in all questions regarding my PhD thesis. I would like to thank all members of the laboratory team (Christine, Kathrin, Juan, Julie, Laili, Luisa, Marcel, Marco, Mareen, Michael, Petra, Pia) for the creative work atmosphere and the lunch breaks at the canteen. Especially, I would like to thank Marco and Pia who supported me in the measurement of the samples, especially for the clinical study. Also, I am thankful for the support and advice in all questions regarding analytical aspects of my work and technical issues of the HPLCs. For the later one, I also would like to
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