Pantoprazole
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Neutropenia in an elderly patient: case report An 82-year-old woman started receiving pantoprazole 40 mg twice daily [route not stated] for gastric ulcers secondary to Stevens Johnson syndrome. Three days later, her WBC and absolute neutrophil count decreased to 2.66 × 109/L and 0.5 × 109/L, respectively. Pantoprazole was discontinued and her WBC and absolute neutrophil count recovered the following day. She was re-challenged with pantoprazole and her WBC and absolute neutrophil count again decreased; both levels normalised after pantoprazole discontinuation. Author comment: "The Naranjo probability scale yielded a score of 9 meaning that there is a "definite" probability pantoprazole was the cause of this adverse drug reaction." Cascetta K, et al. Pantoprazole-induced neutropenia. Journal of Hospital Medicine 7 (Suppl. 2): 172, Mar 2012. Available from: URL: http://dx.doi.org/10.1002/ 803070183 jhm.1927 - USA
0114-9954/10/1402-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 19 May 2012 No. 1402
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