Intracellular localization of beta-catenin expression plays a possible prognostic role on the outcome of hepatoblastoma
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ORIGINAL ARTICLE
Intracellular localization of beta‑catenin expression plays a possible prognostic role on the outcome of hepatoblastoma patients Ulgen Celtik1 · Zafer Dokumcu1 · Emre Divarci1 · Ezgi Guler2 · Eda Ataseven3 · Deniz Nart4 · Funda Yilmaz4 · Ahmet Celik1 · Orkan Ergün1 Accepted: 8 May 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Wnt/Beta-catenin pathway plays an essential role in liver development and regeneration. Abnormal activation in this pathway leads to development of hepatoblastoma (HB). Although its importance has invoked attention, its prognostic role is debatable. We aimed to evaluate the significance of intracellular localization of beta-catenin (BC) expression in the outcome of hepatoblastoma patients. Methods Medical records of HB patients between 2004 and 2018 were reviewed. Patients were grouped according to intracellular localization of BC expression by immunohistochemistry as being cytoplasmic or nuclear. Demographics, radiological images, PRETEXT classifications, vascular involvement, risk groups, chemotherapy responses, and survival rates were analyzed and compared between groups. Results There were 41 patients. Thirteen patients were excluded for unavailability of records in four, negative/unclear BC expressions in seven. Cytoplasmic expression of BC was observed in 17 patients whereas 13 patients displayed nuclear expression. Demographics were similar in both groups. Cytoplasmic BC expression was associated with poor chemotherapy response (p = 0.001) and increased vascular involvement (p = 0.0162) requiring more extensive surgeries (p = 0.039). Conclusion Although the numbers are limited in our series, the intracellular localization of BC expression has been found to be a promising determining factor for hepatoblastoma prognosis. With larger patient series, more reliable results can be achieved. Keywords Hepatoblastoma · Beta-catenin · Childhood liver tumor · Immunohistochemistry · Prognosis
* Orkan Ergün [email protected]
Funda Yilmaz [email protected]
Ulgen Celtik [email protected]
Ahmet Celik [email protected]
Zafer Dokumcu [email protected]
1
Emre Divarci [email protected]
Faculty of Medicine, Department of Pediatric Surgery, Ege University, 35100 Izmir, Turkey
2
Ezgi Guler [email protected]
Faculty of Medicine, Department of Radiology, Ege University, 35100 Izmir, Turkey
3
Eda Ataseven [email protected]
Faculty of Medicine, Department of Pediatric Oncology, Ege University, 35100 Izmir, Turkey
4
Faculty of Medicine, Department of Pathology, Ege University, Izmir, Turkey
Deniz Nart [email protected]
13
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Introduction Hepatoblastoma is the most common malignant tumor of the liver in pediatric age group [1]. Pathogenesis of hepatoblastoma still remains unclear. It is an embryonic tumor which originates from primitive hepatic stem cells [1, 2]. It may be associated with genetic malformations or syndromes such as Beckwith–Wied
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