Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalge
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BioMed Central
Open Access
Research
Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans Takahiro Ushida*1,2,3, Osamu Iwatsu2, Kazuhiro Shimo1, Tomoko Tetsunaga2, Masahiko Ikeuchi2, Tatsunori Ikemoto2,3, YoungChang P Arai1, Katsutoshi Suetomi1 and Makoto Nishihara1 Address: 1Multidisciplinary Pain Center, Aichi Medical University, 21 Karimata, Yazako, Nagakute, Aichi 480-1195, Japan, 2Department of Orthopaedic Surgery, Kochi Medical School, Kohasu, Okoh-cho, Nankoku, Kochi 783-8505, Japan and 3Nankoku Pain Research Group, Kochi Medical School, Kohasu, Okoh-cho, Nankoku, Kochi 783-8505, Japan Email: Takahiro Ushida* - [email protected]; Osamu Iwatsu - [email protected]; Kazuhiro Shimo - [email protected]; Tomoko Tetsunaga - [email protected]; Masahiko Ikeuchi - [email protected]; Tatsunori Ikemoto - [email protected]; Young-Chang P Arai - [email protected]; Katsutoshi Suetomi - [email protected]; Makoto Nishihara - [email protected] * Corresponding author
Published: 28 August 2009 Journal of Neuroinflammation 2009, 6:25
doi:10.1186/1742-2094-6-25
Received: 29 April 2009 Accepted: 28 August 2009
This article is available from: http://www.jneuroinflammation.com/content/6/1/25 © 2009 Ushida et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Although magnesium ions (Mg2+) are known to display many similar features to other 2+ charged cations, they seem to have quite an important and unique role in biological settings, such as NMDA blocking effect. However, the role of Mg2+ in the neural transmission system has not been studied as sufficiently as calcium ions (Ca2+). To clarify the sensory effects of Mg2+ in peripheral nervous systems, sensory changes after intradermal injection of Mg2+ were studied in humans. Methods: Magnesium sulphate, magnesium chloride and saline were injected into the skin of the anterior region of forearms in healthy volunteers and injection-induced irritating pain ("irritating pain", for short), tactile sensation, tactile pressure thresholds, pinch-pain changes and intolerable heat pain thresholds of the lesion were monitored. Results: Flare formation was observed immediately after magnesium sulphate or magnesium chloride injection. We found that intradermal injections of magnesium sulphate and magnesium chloride transiently caused irritating pain, hypesthesia to noxious and innocuous mechanical stimulations, whereas secondary hyperalgesia due to mechanical stimuli was not observed. In contrast to mechanical stimuli, intolerable heat pain-evoking temperature was significantly decreased at the injection site. In addition to these results, spontaneous pain was immediately attenuated
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