Neuroprotective magnesium sulfate administration increases maternal Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocy
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MATERNAL-FETAL MEDICINE
Neuroprotective magnesium sulfate administration increases maternal Neutrophil‑to‑Lymphocyte Ratio, Platelet‑to‑Lymphocyte Ratio and Systemic Immune‑Inflammation Index Gokcen Orgul1 · Tugba Agbal1 · Sevki Celen1 · Ali Turhan Caglar1 Received: 19 August 2020 / Accepted: 29 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose We aimed to analyze the linear changes of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Systemic Immune-Inflammation Index (SII) levels in pregnant women who administrated magnesium sulfate for fetal neuroprotection. Methods This retrospective study included 63 pregnant women who underwent neuroprotective magnesium sulfate administration during January 2015 and July 2020. Women with co-existing diseases or obstetric complications such as preeclampsia, gestational diabetes mellitus, suspicion of chorioamnionitis etc. excluded. The laboratory test results were obtained for each participant. Three results were compared; (1) Before magnesium sulfate-0th hour, (2) 6 h and (3) 12 h after starting loading dose. Results The mean NLR was 7.18 ± 5.14 in patients before treatment. The mean NLR increased to 10.09 ± 4.77 and 10.04 ± 4.35 at 6th and 12th hour of magnesium sulfate treatment. The mean PLR was also increased after starting neuroprotective magnesium sulfate (170.35 ± 89.09 at the beginning; 209.85 ± 88.77 at 6th hour and 209.24 ± 76.66 at 12th hour). The mean SII was found to be increased from 1783.33 ± 1367.29 to 2517.15 ± 1325.77 with magnesium sulfate treatment. However, no statistically significant difference was observed in terms of SII between 6 and 12th hours of treatment (p = 0.752). Maternal serum magnesium levels at 6th and 12th hour were found to be not correlated with NLR, PLR and SII. Conclusion We demonstrated that values of NLR, PLR and SII at 6th hour were all increased after starting magnesium sulfate. Levels of these systemic inflammatory indices were similar at 6th and 12th hour of therapy. Keywords Magnesium sulfate · Neutrophil to lymphocyte ratio · Platelet to lymphocyte ratio · Systemic immuneinflammation index
Introduction Preterm birth is an important health problem and related to increased perinatal morbidity and mortality rates. Long term complications secondary to cerebral palsy have serious consequences for surviving fetuses [1]. Magnesium sulfate is known to be an effective agent when used to protect the immature fetal brain. The risk of adverse neurological outcomes may be decreased by the use of prenatal magnesium * Gokcen Orgul [email protected] 1
Department of Perinatology, Etlik Zubeyde Hanim Women’s Health Care, Training and Research Hospital, University of Health Sciences, 06050 Yenimahalle, Ankara, Turkey
sulfate administration [2, 3]. Several societies such as Word Health Organization (WHO), American College of Obstetricians and Gynecologist (ACOG) and National Institute of Health and Care Excellence recommend administration of magnesium sulfate fo
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