Investigation of the nano-hydroxyapatite with different surface modifications on the properties of poly(lactide-co-glyco
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ORIGINAL CONTRIBUTION
Investigation of the nano-hydroxyapatite with different surface modifications on the properties of poly(lactide-co-glycolide acid) /poly(trimethylene carbonate)/nano-hydroxyapatite composites Jin Qi 1,2 & Jianping Xiao 1 & Tianyao Zhang 1 & Yu Zhang 1,2 & Chengdong Xiong 1 Received: 23 August 2020 / Revised: 15 October 2020 / Accepted: 4 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Nano-hydroxyapatite (HA) was successfully treated by three different surface modification methods of oleic acid (OA), silane coupling agent γ-aminopropyl triethoxysilane (KH550), and ethenyltrimethoxysilane (YDH171), respectively. Then, the treated HA and unmodified HA with 8 wt% were introduced into PLGA/PTMC blends, respectively. And the fracture morphology, thermal property, crystallization behavior, mechanical properties, surface wettability, and in vitro bioactivity of PLGA/PTMC/ HA ternary composites were investigated. The results showed that the PLGA/PTMC/HA composite with the HA surface modified by OA had the highest mechanical properties, while the PLGA/PTMC/HA composite with the HA treated by silane coupling agent YDH171 had the excellent toughness, compared to the other samples. Moreover, the cells’ proliferation results confirmed that the ternary composites exhibited better biocompatibility. All the results suggested that the surface modification of HA was an ideal method in this study, and they would be potential to be used in the field of bone repair in the future. Keywords Nano-hydroxyapatite . Modification . Composites . Mechanical property . Bioactivity
Introduction Total or partial bone defect is the most serious and costly problem in human health [1, 2]. Autografting and allografting are the conventional treatment procedures towards the bone defect [3, 4]. The autogenous bone graft is the best suitable choice for the osteogenesis; however, it also has some disadvantages, which include the inflammation or infection and a limited supply and donor site morbidity. The defects of allogenous bone graft include the disease transmission and their lower osteogenesis effect than that of the autograft [5]. To overcome the shortcomings of the transplantation of the bone graft, tissue engineering has been considered as a feasible approach to repair and reconstruct the bone defects [6]. Therefore, tissue engineering plays an important role in treating the bone-related defects [7]. * Chengdong Xiong [email protected] 1
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China
2
University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China
Compared with metal material, degradable polymers are a kind of non-toxic polymer materials, which can be hydrolyzed or enzymatically decomposed in the body and can also be absorbed by the human body. This kind of polymer has been widely used in clinic and is still being updated and developed. The common typical synthetic degradable polymers include poly(L
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