IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal databases on quantification
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ORIGINAL ARTICLE
IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal databases on quantification Takahiro Konishi1 • Kenichi Nakajima2 • Koichi Okuda3 • Hiroto Yoneyama1 Shinro Matsuo2 • Takayuki Shibutani4 • Masahisa Onoguchi4 • Seigo Kinuya2
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Received: 24 December 2016 / Accepted: 3 April 2017 Ó The Japanese Society of Nuclear Medicine 2017
Abstract Objective Although IQ-single-photon emission computed tomography (SPECT) provides rapid acquisition and attenuation-corrected images, the unique technology may create characteristic distribution different from the conventional imaging. This study aimed to compare the diagnostic performance of IQ-SPECT using Japanese normal databases (NDBs) with that of the conventional SPECT for thallium-201 (201Tl) myocardial perfusion imaging (MPI). Methods A total of 36 patients underwent 1-day 201Tl adenosine stress–rest MPI. Images were acquired with IQSPECT at approximately one-quarter of the standard time of conventional SPECT. Projection data acquired with the IQ-SPECT system were reconstructed via an ordered subset conjugate gradient minimizer method with or without scatter and attenuation correction (SCAC). Projection data obtained using the conventional SPECT were reconstructed
& Kenichi Nakajima [email protected] Takahiro Konishi [email protected] 1
Department of Radiology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, Japan
2
Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, Japan
3
Department of Physics, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan
4
Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan
via a filtered back projection method without SCAC. The summed stress score (SSS) was calculated using NDBs created by the Japanese Society of Nuclear Medicine working group, and scores were compared between IQSPECT and conventional SPECT using the acquisition condition-matched NDBs. The diagnostic performance of the methods for the detection of coronary artery disease was also compared. Results SSSs were 6.6 ± 8.2 for the conventional SPECT, 6.6 ± 9.4 for IQ-SPECT without SCAC, and 6.5 ± 9.7 for IQ-SPECT with SCAC (p = n.s. for each comparison). The SSS showed a strong positive correlation between conventional SPECT and IQ-SPECT (r = 0.921 and p \ 0.0001), and the correlation between IQ-SPECT with and without SCAC was also good (r = 0.907 and p \ 0.0001). Regarding diagnostic performance, the sensitivity, specificity, and accuracy were 80.8, 78.9, and 79.4%, respectively, for the conventional SPECT; 80.8, 80.3, and 82.0%, respectively, for IQ-SPECT without SCAC; and 88.5, 86.8, and 87.3%, respectively, for IQSPECT with SCAC, respectively. The area under the curve obtained via receiver operating characteristic analysis were 0.77, 0.80, and 0.86 for conventional SPECT, IQ-SPECT without
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