Iron-Induced Necrotic Brain Cell Death in Rats with Different Aerobic Capacity
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ORIGINAL ARTICLE
Iron-Induced Necrotic Brain Cell Death in Rats with Different Aerobic Capacity Mingzhe Zheng & Hanjian Du & Wei Ni & Lauren G. Koch & Steven L. Britton & Richard F. Keep & Guohua Xi & Ya Hua
Received: 5 November 2014 / Revised: 16 January 2015 / Accepted: 21 January 2015 # Springer Science+Business Media New York 2015
Abstract Brain iron overload has a key role in brain injury after intracerebral hemorrhage (ICH). Our recent study demonstrated that ICH-induced brain injury was greater in low capacity runner (LCR) than in high capacity runner (HCR) rats. The present study examines whether iron-induced brain injury differs between LCRs and HCRs. Adult male LCR and HCR rats had an intracaudate injection of iron or saline. Rats were euthanized at 2 and at 24 h after T2 magnetic resonance imaging, and the brains were used for immunostaining and Western blotting. LCRs had more hemispheric swelling, T2 lesion volumes, blood-brain barrier disruption, and neuronal death at 24 h after iron injection (p
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