Mitochondria and Cell Death
This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processe
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David M. Hockenbery Editor
Mitochondria and Cell Death
Cell Death in Biology and Diseases
Series Editors Xiao-Ming Yin Zheng Dong
More information about this series at http://www.springer.com/series/8908
David M. Hockenbery Editor
Mitochondria and Cell Death
Editor David M. Hockenbery Clinical Research Divison Fred Hutchinson Cancer Research Center Seattle, WA, USA
Cell Death in Biology and Diseases ISBN 978-1-4939-3610-6 ISBN 978-1-4939-3612-0 DOI 10.1007/978-1-4939-3612-0
(eBook)
Library of Congress Control Number: 2016934848 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface
This volume provides an in-depth, up-to-date collection of papers on mitochondrial biology in the context of the cellular environment, and the roles of mitochondria in cell death and the various cellular programs that can intersect with cell death pathways (intracellular signaling, homeostasis, and pathogen resistance). There has been a surge in interest in mitochondrial functions in the last 5 years, with substantial new understanding in the areas of mitochondrial organelle and protein homeostasis, mitochondrial dynamics, interorganelle associations, and integration within diverse cellular programs. This progress has led to novel insights into the important place of mitochondria in orchestrating these programs. The importance of mitochondrial dysfunction in pathogenesis of clinical diseases, including neurodegenerative diseases, cancer, metabolic syndrome, and aging, illustrates the strong relevance of these topics in “bench to bedside” investigations. The chapter authors are renowned experts in their fields, actively contributing to the expansion of modern mitochondrial research. The earliest and best known function of mitochondria, generation of ATP from proton motive force, le
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