Necrotic Cell Death
This essential volume in the Cell Death in Biology and Diseases series presents comprehensive coverage of necrosis from recognized experts at leading academic and medical institutions around the world, thus keeping pace with the emerging research interest
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Han-Ming Shen Peter Vandenabeele Editors
Necrotic Cell Death
Cell Death in Biology and Diseases
Series Editors Xiao-Ming Yin Zheng Dong
For further volumes: http://www.springer.com/series/8908
Han-Ming Shen • Peter Vandenabeele Editors
Necrotic Cell Death
Editors Han-Ming Shen Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore, Singapore
Peter Vandenabeele Department of Biomedical Molecular Biology (UGent) Inflammation Research Center (VIB) VIB/University of Ghent Zwijnaarde, Belgium
ISBN 978-1-4614-8219-2 ISBN 978-1-4614-8220-8 (eBook) DOI 10.1007/978-1-4614-8220-8 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014932044 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
Series Preface
Cell death, or conversely cell survival, is a major biological phenomenon. Just as with cell proliferation and cell differentiation, cell death is a choice that a cell has to make, sometimes voluntarily, other times accidentally. As such, cell death serves a purpose in the biology of a multicellular organism. The machinery of cell death and that of cell protection are evolutionarily conserved and their ele
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