Is exposure to environmental factors associated with a characteristic clinical and laboratory profile in systemic sclero
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Rheumatology International https://doi.org/10.1007/s00296-020-04693-3
INTERNATIONAL
OBSERVATIONAL RESEARCH
Is exposure to environmental factors associated with a characteristic clinical and laboratory profile in systemic sclerosis? A retrospective analysis Lisbeth A. Aguila1 · Henrique Carriço da Silva1 · Ana Cristina Medeiros‑Ribeiro1 · Bruna Giusto Bunjes1 · Ana Paula Luppino‑Assad1 · Percival D. Sampaio‑Barros1 Received: 24 February 2020 / Accepted: 20 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract To identify environmental factors (EF) in a large cohort of patients with systemic sclerosis (SSc) analyzing their clinical and laboratory presentation. A cohort of consecutive patients attended at a single Brazilian SSc outpatient clinic was analyzed regarding EF. Data were analyzed according to clinical, demographic and laboratory characteristics, as well as SSc subtype. In a cohort of 662 patients, 70 (10.6%) had known previous exposure to EF, predominantly organic solvents (51.4%), silica (20%), silicone (12.9%) and pesticides (11.4%). In the SSc cohort, patients with EF had a significantly higher frequency of male gender (p
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