Is there any association between primary hyperparathyroidism and ocular changes, such as central corneal thickness, reti
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ORIGINAL ARTICLE
Is there any association between primary hyperparathyroidism and ocular changes, such as central corneal thickness, retinal thickness, and intraocular pressure? Husniye Baser1,4 • Neslihan Cuhaci2 • Oya Topaloglu2 • Fatma Yulek3 Nagihan Ugurlu3 • Reyhan Ersoy2 • Nurullah Cagil3 • Bekir Cakir2
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Received: 4 April 2015 / Accepted: 18 August 2015 / Published online: 29 August 2015 Ó Springer Science+Business Media New York 2015
Abstract Ocular changes are commonly encountered in various endocrine disorders. However, only a few studies have reported ocular changes in patients with primary hyperparathyroidism (PHPT). Here, we examined the central corneal thickness (CCT), retinal thickness (RT), and intraocular pressure (IOP), and their relationships with serum intact parathyroid hormone (iPTH), calcium (Ca), and phosphorus (P) levels in patients with PHPT. Thirtyseven eyes of 37 PHPT patients were compared with 43 eyes of 43 age- and sex-matched normal subjects. A detailed ophthalmologic examination, including CCT, RT, and IOP, was performed. CCT and IOP in PHPT patients were significantly higher than controls (p = 0.024 and p = 0.038, respectively). No statistically significant difference was detected in RT between the two groups (p = 0.730). iPTH levels were positively correlated with CCT and IOP (r = 0.304, p = 0.006 and r = 0.249, p = 0.026, respectively). No significant correlation was found between iPTH levels and RT (p [ 0.05), and between serum Ca levels, and RT, CCT, and IOP (all, p [ 0.05). While there was a negative correlation between serum P levels and CCT (r = -0.264, p = 0.018), no correlation was observed between serum P levels, and RT and IOP (both, p [ 0.05). Using multiple regression & Husniye Baser [email protected] 1
Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Ankara, Turkey
2
Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
3
Department of Ophthalmology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
4
Ovecler, 1297 Sokak, No. 1/22, 06460 Ankara, Turkey
analyses, iPTH, serum Ca, and serum P levels were found to have no significant associations with CCT, IOP, and RT (all, p [ 0.05). There was no significant association between PHPT, and CCT, RT, and IOP. We postulate that the identification of ocular aspects of PHPT is significant, and further studies related to this condition are required. Keywords Primary hyperparathyroidism Central corneal thickness Retinal thickness Intraocular pressure
Introduction Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. Biochemical signs of PHPT involve elevated serum calcium (Ca) levels in the presence of elevated or abnormal levels of parathyroid hormone (PTH). While a sporadic PTH secreting adenoma of parathyroid chief cells causes PHPT in about 85 % of patients, multiglandular hyperplasia is seen in 1–15 % of all cases with PHPT. Parathyroid carcinoma is very rare and occurs
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