Isoniazid
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Acute kidney injury: case report A 74-year-old man developed acute kidney injury during prophylactic treatment with isoniazid for latent tuberculosis. The man had a medical history of ileal Crohn’s disease and underwent resective surgery for obstructive complications. He presented with asymptomatic early severe endoscopic post-operative recurrence 6 months following the surgery. Thus, he started received unspecified anti-TNF alpha treatment and isoniazid prophylaxis 5 mg/kg [route and frequency not stated] for latent tuberculosis infection, which was diagnosed at pre-biologic screening. After 2 weeks, he was admitted due to acute renal failure. His serum creatinine was 5.8 mg/dL and glomerular filtration rate was 8.9 mL/min. His other medical history was significant for mild arterial hypertension, which was treated with unspecified ACE-inhibitors. Subsequently, isoniazid was stopped, and the man was treated with fluid replacement. After a few days, a full recovery of the renal function was noted. Two weeks following the discharge, his renal function was in the normal range. The man was re-challenged with isoniazid, and after a few days, the serum creatinine level increased again above 2.5 mg/dL. Thus, isoniazid was stopped and the creatinine level normalised. Second-line chemoprophylaxis with rifampicin was then started and he did not experience any adverse events. It was concluded that the acute kidney injury was caused by isoniazid. De Biasio F, et al. Acute kidney injury: an unexpected Isoniazid-related adverse event in a patient with Crohn's disease receiving prophylactic treatment for latent 803500649 tuberculosis. Digestive and Liver Disease 52: 1065-1066, No. 9, Sep 2020. Available from: URL: http://doi.org/10.1016/j.dld.2020.04.033
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Reactions 12 Sep 2020 No. 1821
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