Isoniazid
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Isoniazid Pure red cell aplasia: case report
A 35-year-old man developed pure red cell aplasia (PRCA) during treatment with isoniazid for tuberculosis. The man, who had tuberculosis, had been receiving isoniazid [dosage and route not stated], rifampin, pyrazinamide and ethambutol for one month. He was hospitalised with normocytic-normochromic-anaemia. On admission, lab tests showed haemoglobin of 6.1 g/dL, WBC of 5600 cells/mm3, platelet count of 2.5 lakhs/mm3 and IRF of 0%. His bone marrow biopsy showed hypocellular with normoblastic erythropoiesis. He was diagnosed with isoniazid-induced PRCA. Isoniazid was discontinued. Fifteen days after discontinuation of isoniazid, lab tests showed reticulocyte of 8% and haemoglobin of 9.4 g/dL. Badami SR. Isoniazid Induced Acquired Pure Red Cell Aplasia: A Rare Case Report. Journal of the Association of Physicians of India 68: 99, No. 1, Jan 2020
0114-9954/20/1818-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
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Reactions 22 Aug 2020 No. 1818
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