Isotretinoin
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Central hypothyroidism: case report An 18-year-old woman developed central hypothyroidism during treatment with isotretinoin for acne vulgaris. The woman was admitted due to abnormal thyroid function tests. She had no symptoms of hypothyroidism except for weakness and fatigue. She did not have any family history of hypothyroidism. Her only medication was oral isotretinoin 20 mg/day for acne vulgaris. She had no history of drug or alcohol use or smoking. Physical examination did not show evidence of hypothyroidism. Reexamination of her thyroid function tests showed a decreased free thyroxine (fT4) value of 0.74 ng/dL and TSH value of 0.023 µIU/mL. Thus, she was diagnosed with central hypothyroidism secondary to isotretinoin. Sella MRI revealed no pathology. Clinical and laboratory findings indicated central hypothyroidism [duration of treatment to reaction onset not stated]. The woman started receiving treatment with levothyroxine sodium [levothyroxine]. Isotretinoin was discontinued. After two weeks of levothyroxine sodium treatment, her blood hormone levels during testing showed free triiodothyronine (fT3) of 2.95 ng/dL, fT4 was 0.95 ng/dL and TSH was 1.133 µIU/mL. Her symptoms improved after the treatment. Repeat thyroid function tests after 6 months showed results within normal limits. Calapkulu M, et al. A rare cause of central hypothyroidism: oral isotretinoin treatment. Hong Kong Journal of Dermatology and Venereology 27: 127-130, No. 3, 2019. 803501667 Available from: URL: http://medcomhk.com/hkdvb/details.asp?id=890&show=1234
0114-9954/20/1822-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 19 Sep 2020 No. 1822
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