Kidney function and other factors and their association with falls
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RESEARCH
Open Access
Kidney function and other factors and their association with falls The screening for CKD among older people across Europe (SCOPE) study Sabine Britting1, Rada Artzi-Medvedik2, Paolo Fabbietti3,4* , Lisanne Tap5, Francesco Mattace-Raso5, Andrea Corsonello3, Fabrizia Lattanzio3, Johan Ärnlöv6,7,8, Axel C. Carlsson6,7, Regina Roller-Wirnsberger9, Gerhard Wirnsberger10, Tomasz Kostka11, Agnieszka Guligowska11, Francesc Formiga12, Rafael Moreno-Gonzalez12, Pedro Gil13, Sara Lainez Martinez13, Robert Kob1, Itshak Melzer14†, Ellen Freiberger1† and on behalf of the SCOPE investigators
Abstract Background: Reduced kidney function has become a major public health concern, especially among older people, as Chronic Kidney Disease (CKD) is associated with increased risk of end stage renal disease and mortality. Falls are a serious negative health outcome in older persons with one third of people aged 65 years experiencing a fall per year and increasing fall rates with increasing age. The impact of CKD on falls in older community-dwelling persons is not well investigated. Additionally, lower urinary tract symptoms (LUTS) may also increase the risk of falls. Therefore, our aim was to investigate the impact of CKD and LUTS on falls as well as on injurious falls. Methods: The SCOPE study is an observational, multinational, multicenter, prospective cohort study involving communitydwelling older persons aged 75 years and more recruited from August 2016 to March 2018 in seven European countries. The main outcomes of the present study were any falls and any injurious falls during the 12 months before enrolment. The cross-sectional association of estimated glomerular filtration rate (eGFR) and LUTS with study outcomes was investigated by logistic regression analysis adjusted for baseline characteristics of enrolled subjects. (Continued on next page)
* Correspondence: [email protected] † Itshak Melzer and Ellen Freiberger contributed equally to this work. 3 Italian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy 4 Laboratory of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCA, Via S. Margherita 5, 60124 Ancona, Italy Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To
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