Kinase Signaling Networks
This detailed volume describes cutting-edge techniques in three distinct and complementary areas of contemporary kinase biology research. Beginning with a section on synthetic biology, chemical biology, and screening approaches to kinase signaling network
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Aik-Choon Tan Paul H. Huang Editors
Kinase Signaling Networks
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire, Hatfield Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Kinase Signaling Networks Edited by
Aik-Choon Tan Division of Medical Oncology University of Colorado Aurora, CO, USA
Paul H. Huang Protein Networks Laboratory Institute of Cancer Research London, UK
Editors Aik-Choon Tan Division of Medical Oncology University of Colorado Aurora, CO, USA
Paul H. Huang Protein Networks Laboratory Institute of Cancer Research London, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7152-7 ISBN 978-1-4939-7154-1 (eBook) DOI 10.1007/978-1-4939-7154-1 Library of Congress Control Number: 2017944761 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface
A multitude of fundamental cellular processes are driven by a class of ~90 proteins known as kinases, including cell division, DNA replication and repair, cell death, and differentiation. Kinases typically exist in a steady-state inhibited conformation which upon activation initiates a series of downstream signaling cascades, known as signaling networks. Aberrations in the expression and regulation of kinases are major causes of human disease, including cancer, diabetes, atherosclerosis, and infectious disease, among others. It is therefore unsurprising that kinases represent the largest class of proteins for which drugs have been developed. In some instances, these drugs have revolut
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