Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review
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(2020) 18:282
RESEARCH
Open Access
Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review Jianjun Xu1†, Shaobo Hu1,2†, Suzhen Li3, Weimin Wang1, Xing Zhou1, Yuzhe Wu1, Zhe Su1, Xiang Cheng1, Yang Gao1* and Qichang Zheng1*
Abstract Background: Hepatic epithelioid hemangioendothelioma (HEHE) is an extremely rare borderline tumor of vascular endothelial origin. Laparoscopic resection of HEHE has never been reported. Methods: The clinical data of eleven patients with HEHE (4 women and 7 men) who were diagnosed and treated at the Union Hospital (Wuhan, China), and Wuhan Asia General Hospital (Wuhan, China), between March 2012 and July 2020 were analyzed retrospectively. Results: The mean age of HEHE patients was 42.4 ± 13.9 years (range 22–67 years). All patients underwent laparoscopic surgery alone or in combination with radiofrequency ablation. Most tumors showed aggressive growth or metastasis. By immunohistochemistry, tumor cells were positive for CD31, CD34, ERG, PCK, FLi-1, TFE-3, and Ki-67 (labeling index range, 5–15%). In one of the patients, the tumor was accompanied by partial necrosis with a local appearance of epithelioid angiosarcoma. Postoperative adjuvant treatment included chemotherapy, sorafenib, and Huaier granule. As of July 2020, the median follow-up duration was 36 months (range, 9–60 months), with 2 (18.2%) patients experiencing tumor recurrence. Conclusions: This is the first report of laparoscopic hepatectomy of HEHE. Curative laparoscopic hepatectomy might be an acceptable treatment for appropriate HEHE patients. Keywords: Hepatic epithelioid hemangioendothelioma, Liver neoplasms, Laparoscopic hepatectomy, Targeted therapy
* Correspondence: [email protected]; [email protected] Disclosure of significance: To the best of our knowledge, laparoscopic resection of HEHE has never been described in the literature. This is the first report of laparoscopic resection of hepatic epithelioid hemangioendothelioma. † Jianjun Xu and Shaobo Hu contributed equally to this work. 1 Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the cop
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