Imaging characteristics and prognostic values of hepatic epithelioid hemangioendothelioma on 18 F-FDG PET/CT
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ORIGINAL ARTICLE
Imaging characteristics and prognostic values of hepatic epithelioid hemangioendothelioma on 18F‑FDG PET/CT Weimin Wang1 · Guobing Liu1 · Pengcheng Hu1 · Lifang Pang1 · Taoying Gu1 · Haojun Yu1 · Rongkui Luo2 · Xinrong Yang3 · Hongcheng Shi1 Received: 3 March 2020 / Accepted: 1 August 2020 © Springer Nature Switzerland AG 2020
Abstract Hepatic epithelioid hemangioendothelioma (HEHE) is a low-to-intermediate-grade malignant mesenchymal tumor. The diagnostic and prognostic values of 2-[18F] fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to patients with HEHE have not been fully validated. Patient survival outcomes (including overall survival [OS] and progression-free survival [PFS]), lesions characteristics and semi-quantitative parameters, in terms of maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) on 18F-FDG PET/CT of 20 cases with HEHE were measured and analyzed. A total of 310 liver lesions were detected (excluding the diffuse-type lesions in 3 cases). Most lesions had higher SUVmax in delayed imaging than in early imaging (P = 0.013). Patients with multiple organs involved had higher death rate (P = 0.022), higher progression rate (P = 0.020), shorter OS (P = 0.011), larger lesion S UVmax (P = 0.048) and TLG (P = 0.033) than those with only liver involved. The area under curves (AUCs) from the receiver operating characteristic (ROC) curve analysis were 0.960, 0.949, 0.980 and 0.960 for SUVmax, SUVpeak, TLG and MTV, respectively, in predicting OS (P = 0.005, 0.008, 0.001 and 0.024, respectively). For predicting PFS, the AUCs were 0.791, 0.824, 0.857 and 0.813 (P = 0.036, 0.019, 0.010 and 0.024), respectively. Dual-timepoint imaging may improve lesions detectability. Patients with multiple organ involved had worse prognosis. The higher SUVmax, SUVpeak, TLG and MTV of lesions, the worse prognosis of patients were found. Keywords Hepatic epithelioid hemangioendothelioma · 2-[18F] fluoro-2-deoxy-D-glucose (18F-FDG) · Positron emission tomography/computed tomography (PET/CT) · Prognosis
Weimin Wang and Guobing Liu contributed equally to this work. * Hongcheng Shi [email protected]
Xinrong Yang yang.xinrong@zs‑hospital.sh.cn
Weimin Wang [email protected]
1
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 in Fenglin Road, Shanghai 200032, People’s Republic of China
2
Department of Pathology, Zhongshan Hospital, Fudan University, No. 180 in Fenglin Road, Shanghai 200032, People’s Republic of China
3
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, No. 1609 in Xietu Road, Shanghai 200032, People’s Republic of China
Guobing Liu [email protected] Pengcheng Hu hu.pengcheng@zs‑hospital.sh.cn Lifang Pang pang.lifang@zs‑hospital.sh.cn Taoying Gu gu.taoying@zs‑hospital.sh.cn Haojun Yu yu.haojun
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