Lateral Flow Immunoassay
Due to the simplicity, relative accuracy, fast result reporting, and user-friendliness of lateral flow immunoassay, its use has undergone tremendous growth in the diagnostic industry in the last few years. Such technology has been utilized widely and incl
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Raphael C. Wong
l
Harley Y. Tse
Editors
Lateral Flow Immunoassay
13
Editors Raphael C. Wong Branan Medical Corporation 10015 Muirlands Road Irvine, CA 92618 USA [email protected]
ISBN: 978-1-58829-908-6 DOI 10.1007/978-1-59745-240-3
Harley Y. Tse Wayne State University School of Medicine Department of Immunology and Microbiology 540 E. Canfield Avenue Detroit, MI 48201 USA [email protected]
e-ISBN: 978-1-59745-240-3
Library of Congress Control Number: 2008939893 # Humana Press, a part of Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper springer.com
To our families for their patience and support during the preparation of this book. This book epitomizes the friendship and collaboration of the co-editors for over forty years.
Preface
Since its initial development in the 1980s, the technology of Lateral Flow Immunoassay has gained wide acceptance. The main reason for its popularity is the simplicity of the test design. The lateral flow immunoassay devices are compact and easily portable. Most of them do not require external reagent for results. Addition of a liquid sample would initiate and complete the test. Results are quick and easy to interpret, usually without the help of an instrument. The technology is also powerful. Multiple analytes can be tested simultaneously with a single device. It can also be easily combined with other technology to provide a comprehensive analysis like simultaneous drug and alcohol determinations by the police force in a roadside testing situation. Manufacturing of the test is relatively easy and inexpensive. Advancement in the detection moieties, improvement in material components, availability of better processing equipment, and increased attention to quality manufacturing all contribute to increase in the reliability, accuracy, and applications of the technology. However, the continuing demand for quantitative result and sensitivity has presented great challenge for assay developer. In this book, we have compiled the essence of the current state of the art of this technology and addressed what can be expected in the future. After an introduction on the evolution of the technology, some market information is provided. They are followed by discussions on the various materials, biological and chemical components i
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