Linezolid
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Thrombocytopenia: case report A 7-month-old boy developed thrombocytopenia during treatment with linezolid for Enterococcus faecalis and Acinetobacter baumannii infections. The boy, who was diagnosed with hepatic cholestasis type 2, was scheduled for liver transplantation on 14 December 2016. Imunosuppressive was started with tacrolimus and methylprednisolone. Subsequently, he developed intermittent fever and bile testing revealed Enterococcus faecalis and Acinetobacter baumannii. Thus, from 1 December 2016, he started receiving linezolid 80mg every 8 hours [route not stated]. His initial platelet count was 338 × 103/µL. Two days before the transplant, his platelet count was 354 × 103/µL. He underwent transplant on 14 December 2016 as per schedulee. Ater the surgery, he was administered IV linezolid [dosage not stated] along with meropenem. Thereafter, his platelet count started to decrease. On 15 December 2016, the platelet count was 139 × 103/µL, and on 18 Decemebr 2016, it further declined to 19 × 103/µL. A diagnosis of linezolid-induced thrombocytopenia was made. The boy’s linezolid was stopped on 18 December 2016. Following linezolid discontinuation, platelet count continued to drop over the next 2 days and then it started to improve. Five days after the withdrawal of linezolid, platelet count normalised to up to 149 × 103/µL and it remained normal till discharge. Lu X, et al. Linezolid-induced thrombocytopenia in a child with a liver transplant: A case report. International Journal of Clinical Pharmacology and Therapeutics : no 803515492 pagination, 19 Oct 2020. Available from: URL: http://doi.org/10.5414/CP203754
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Reactions 21 Nov 2020 No. 1831
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