Linezolid
- PDF / 130,817 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 2 Downloads / 144 Views
1
Linezolid Thrombocytopenia in an elderly patient: case report A 74-year-old man developed thrombocytopenia following treatment with linezolid for vancomycin-resistant enterococci abdominal infection. The man developed an abdominal infection following colon resection for diverticulosis; oral linezolid 600mg twice daily was initiated for vancomycin-resistant enterococci infection. On admission, tests showed a creatinine clearance value of between 40 to 60 mL/min consistent with renal dysfunction. His platelet count was 248 000 cells/mm3, on day 1 of linezolid treatment. Declining platelet count values were immediately noted; repeat tests showed a platelet count of 189 000 cells/mm3 on treatment day 2. His platelet count dropped to 97 000 cells/mm3 on day 5. Abdominal fluid tested positive for Pseudomonas aeruginosa sensitive to ceftazidime. Linezolid was withdrawn, and ceftazidime was initiated. The man’s platelet count normalised after 3 days. Author comment: "In our patient case, we attributed thrombocytopenia to linezolid since platelet count had been stable on long-term daily medication regimen until the introduction of linezolid . . . The Naranjo probability scale for adverse drug reactions was used in the present case to determine the likelihood of association between linezolid therapy and thrombocytopenia. Our patient met criteria for a score of 7, suggesting probable association." Poulakos MN, et al. Probable linezolid-induced thrombocytopenia in a patient with vancomycin-resistant enterococci. Journal of Pharmacy Practice 25: 615-618, No. 6, Dec 2012. Available from: URL: http://dx.doi.org/10.1177/0897190012442720 803082638 USA
0114-9954/10/1437-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 2 Feb 2013 No. 1437
Data Loading...
