Lithium
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Lithium Brugada syndrome: case report A 42-year-old man with schizoaffective disorder developed Brugada syndrome during treatment with lithium [dosage not stated; time to reaction onset not clearly stated]. The man, who had been receiving lithium for 8 years and, during this period had a history of recurrent syncope, experienced an episode of syncope. An ECG revealed typical Brugada syndrome signs with ST-segment elevation in his precordial leads (V1–V3); his serum lithium concentration was within the therapeutic range (0.75 mmol/L). He was diagnosed with Brugada syndrome. Lithium was discontinued. However, 3 weeks later, the man developed mania and was hospitalised; he received olanzapine. An ECG revealed that his ST abnormalities had resolved and a programmed electrical stimulation test induced only nonsustained ventricular tachycardia. However, an ajmaline provocation test revealed ST-segment elevations consistent with Brugada syndrome. He underwent implantation of an automatic defibrillator for prevention of syncopes and sudden cardiac death. Laske C, et al. Brugada syndrome in a patient treated with lithium. American 801091375 Journal of Psychiatry 164: 1440-1441, No. 9, Sep 2007 - Germany
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Reactions 22 Sep 2007 No. 1170
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