Living Morphogenesis of the Heart

The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progres­ sively and irreversibly assemble into a segmented, primary heart tube that can be remo

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Roger R. Markwald Medical University of South Carolina

Editorial Advisory Board

Paul Barton National Heart and Lung Institute, London, United Kingdom Clayton Buck University of Pennsylvania Maria V. de fa Cruz Hospital Infantil de Mexico "Federico Gomez", Mexico Mark Fishman Massachusetts General Hospital Adriana Gittenberger-de Groot University of Leiden, The Netherlands Julie Korenberg Cedars-Sinai Medical Center, Los Angeles Wout H. Lamers University of Amsterdam, The Netherlands

Charles Little Medical University of South Carolina John Lough Medical College of Wisconsin Takashi Mikawa Cornell Medical College Jeffrey Robbins Children's Hospital Medical Center, Cincinnati Thomas Rosenquist University of Nebraska Medical School Ray Runyan University of Arizona Robert Schwartz Baylor College of Medicine

Kersti Linask University of Medicine and Dentistry of New Jersey

Books in the Series Vascular Morphogenesis: in vivo, in vitro, in mente C. D. Little, V. A. Mironov and E. H. Sage, editors Living Morphogenesis of the Heart

M. V. de la Cruz and R. R. Markwald

0-8176-3920-9 0-8176-4037-1

Living Morphogenesis

of the Heart Maria Victoria de Ia Cruz Roger R. Markwald Editors

Springer Science+Business Media, LLC

Editors: Maria V. de la Cruz, M.D. Departamento de Biologfa de1 Desarrollo y Tcratogenesis Hospital Infantil de Mexico "Federico G6mez" Mexico, D. F. C. P. 06720 Roger R. Markwald, Ph.D. Department of Ce1l Biology and Anatomy Medical V niversity of Somh Carolina Charleston, SC 29425

Library of Congress Cataloging-in-Publication Data Cataloging in Process

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Legend of cover design. Three photographs of an in vivo labelling experiment in the chick embryo heart. They depict the appearance and the contribution of the primitive interventricular se