Morphogenesis and Maturation of Retroviruses
Retroviruses arguably belong to the most fascinating of all viruses because of their unusual and highly efficient mode of replication involving reverse transcription and integration of the viral genome and a complex system of transcriptional and post tra
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Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama· H. Koprowski, Philadelphia/Pennsylvania· F. Melchers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La Jolla/California· H. Wagner, Munich
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Morphogenesis and Maturation of Retroviruses Edited by H.-G. Krausslich
With 34 Figures
Springer
Professor Dr. HANS-GEORG KRAuSSLICH Heinrich-Pette-Institut fOr Experimentelie Virologie und Immunologie an der Universitat Hamburg Martinistrasse 52 20251 Hamburg Germany
Cover illustration: Human Immunodeficiency virus type-J (HIVJ), thin section electron micrograph (Picture by courtesy of Dr. A. Janetzko, Max-Planck-Institut, Ladenburg, Germany). Colour inserts show ribbon drawings representing molecular models of the three-dimensional structures of the HIV-J Gag proteins matrix (MA; courtesy of Dr. Wesley Sundquist, University of Utah, Salt Lake City, USA), capsid (CA: courtesy of Dr. Michael Rossmann, Purdue University, West Lafayette, USA) and nucleocapsid (NC: courtesy of Dr. M. Summers, University of Maryland, Baltimore, USA). Cover design: Design & Production, Heidelberg ISSN 0070-217X e-ISBN-13:97S-3-642-S0145-7 ISBN-13:97S-3-642-S0147-1 001: 10.1007/97S-3-642-S0145-7 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation. reprinting. reuse of illustrations, recitation. broadcasting. reproduction on microfilm or in any other way. and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9. 1965. in its current version, and permission for use must always be obtained from SpringerVerlag. Violations are liable for prosecution under the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1996 Soft cover reprint of the hardcover 1st edititon 1996 library ot Congress Catalog Card Number 15 - 12910 The use of general descriptive names. registered names. trademarks. etc. in this publication does not imply. even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting other relevant literature. Typesetting Scientific Publishing Services (P) Ltd, Madras SPIN: 10495435 27/3020/SPS - 5 4 3 21 0 - Printed on acid-free paper
Preface
Retroviruses arguably belong to the most fascinating of all viruses because of their unusual and highly efficient mode of replication involving reverse transcription and integration of the viral genome and a complex system of transcriptional and posttranscriptional regulatory mechanisms. The impor
