LncRNA TUG1 promotes esophageal cancer development through regulating PLK1 expression by sponging miR-1294
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ORIGINAL RESEARCH PAPER
LncRNA TUG1 promotes esophageal cancer development through regulating PLK1 expression by sponging miR-1294 Mingzhu Zong . Wanting Feng . Li Wan . Xiaojuan Yu . Weiyong Yu
Received: 22 February 2020 / Accepted: 8 August 2020 Ó Springer Nature B.V. 2020
Abstract Objectives Esophageal cancer is one of the malignant tumor with poor survival. The 5-year survival rate of esophageal cancer patients remains poor due to limited therapeutic options and the development of drug-resistance. Recent evidence suggests that long non-coding RNAs (lncRNAs) are involved in occurrence and development of tumor, however, the molecular mechanisms of lncRNA taurine-upregulated gene 1 (TUG1) in esophageal cancer remain unknown. Results TUG1 was overexpressed in esophageal cancer tissues and cells. The knockdown of TUG1 repressed proliferation and invasion, while promoted apoptosis of esophageal cancer cells by negatively regulating miR-1294 expression. Furthermore, PLK1 was a target mRNA of miR-1294 in esophageal cancer cells. Therefore, the effects of PLK1 silencing on proliferation, apoptosis, and invasion of esophageal cancer cells could be overturned by silencing miR1294. Additionally, TUG1 silencing inhibited growth of tumor cells in vivo. Conclusions TUG1 was found as oncogenic gene in esophageal cancer. Mechanically, TUG1 attributed to
M. Zong W. Feng L. Wan X. Yu W. Yu (&) Department of Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, No. 6, West Beijing Road, Huai’an 223300, Jiangsu, China e-mail: [email protected]
esophageal cancer process by regulating miR-1294/ PLK1 axis. Keywords LncRNA TUG1 miR-1294 PLK1 Esophageal cancer
Introduction Esophageal cancer is a common cancer around the world with poor prognosis (Pennathur et al. 2013). Recurrence and the development of drug-resistance are major obstacles to improve survival time of esophageal cancer patients (Ilson 2008; Ishigaki et al. 2016; Shimada et al. 2003). In addition, the reliable biomarkers to guide diagnosis and management of esophageal cancer are necessary for survival amelioration of patients with esophageal cancer. Consequently, it is indispensable to explore the molecular and underlying pathogenic mechanisms of esophageal cancer. It has been manifested that long non-coding RNAs (lncRNAs) play critical regulator roles in multiple cancers by regulating numerous biological behaviors, including lung squamous cell carcinoma (Zhang et al. 2017b), cervical cancer (Zhang et al. 2017a), and esophageal cancer (Jiao et al. 2016). For example, Zheng et al.. reported that long non-coding RNA plasmacytoma variant translocation 1 (lnc-PVT1)
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Biotechnol Lett
could stimulate invasion of esophageal cancer cells by promoting epithelial-to-mesenchymal transition (EMT) by regulation of E-cadherin and vimentin (Zheng et al. 2016). Another study performed by Dong et al. showed that maternally expressed gene 3 functioned as a novel tumor-inhibitive ln
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