Long noncoding RNAs in head and neck squamous cell carcinoma: biological functions and mechanisms
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REVIEW
Long noncoding RNAs in head and neck squamous cell carcinoma: biological functions and mechanisms Jiayu Zhao1 · Daming Liu1 · Hao Yang1 · Shan Yu2 · Hongjiang He1 Received: 15 April 2020 / Accepted: 28 August 2020 © Springer Nature B.V. 2020
Abstract Head and neck squamous cell carcinoma (HNSCC) is the primary malignant tumor of the oral cavity, larynx, nasopharynx, esophagus and tongue. Although several novel therapeutic methods for HNSCC have been developed, the final therapeutic effect on the patient is still not satisfactory. Thus, it is imperative that scientists identify novel distinguishable markers with specific molecular characteristics that can be used in therapeutic and prognostic evaluation. Previous reports have shown that long noncoding RNAs (lncRNAs) are important regulators of gene expression in many cancers, including head and neck squamous cell carcinomas. Translational studies of lncRNAs in HNSCC are urgently required before their application as a treatment can be realized. We aimed to address the most relevant findings on lncRNAs as biomarkers or treatment targets in head and neck squamous cell carcinoma and to summarize their discovered pathways and mechanisms of action to reveal the possible future applications of these novel biomarkers in clinical translational research. Keywords Head and neck squamous cell carcinoma · Laryngeal squamous cell carcinoma · Nasopharyngeal carcinoma · Oral squamous cell carcinoma · Long noncoding RNA · Biomarkers Abbreviations HNSCC Head and neck squamous cell carcinoma LncRNAs Long noncoding RNAs LSCC Laryngeal squamous cell carcinoma ESCC Esophageal squamous cell carcinoma NPC Nasopharyngeal carcinoma * Shan Yu [email protected] * Hongjiang He [email protected] Jiayu Zhao [email protected] Daming Liu [email protected] Hao Yang [email protected] 1
Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang, China
Department of Pathology, Second Affiliated Hospital of Harbin Medical University, No. 246 XueFu Avenue, Harbin 150086, Heilongjiang, China
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OSCC Oral squamous cell carcinoma TSCC Tongue squamous cell carcinoma EMT Epithelial-mesenchymal transition ncRNA Noncoding RNA miRNA MicroRNA snRNA Small nuclear RNA snoRNA Small nucleolar RNA piRNA Piwi-interacting RNA siRNA Small interfering RNA CASP7 Caspase 7, apoptosis-related cysteine peptidase TERRA Telomeric repeat-containing RNAs MDSCs Myeloid-derived suppressor cells TUG1 Taurine-upregulated gene 1 FTH1P3 Ferritin heavy chain 1 pseudogene 3 PRC2 Polycomb repressive complex 2 CCAT1 Colon cancer-associated transcript-1 CCAT2 Colon cancer-associated transcript-2 LINC00460 Long intergenic non-protein-coding RNA 460 LINC00520 Long intergenic non-protein-coding RNA 520
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Vol.:(0123456789)
Molecular Biology Reports
LIN00668 Long intergenic non-protein-coding RNA 668 SSTR5-AS1 Antisense lncRNA somatostatin receptor 5 NEF Neighboring enhancer of FOXA
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