Long-term changes of aortic 18 F-FDG uptake and calcification in health-screening subjects
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ORIGINAL ARTICLE
Long-term changes of aortic in health-screening subjects
18
F-FDG uptake and calcification
Yoshiharu Ryu • Katsuya Yoshida • Yoshifumi Suzuki • Masashi Nakadate • Isao Umehara • Makoto Tomita • Hitoshi Shibuya
Received: 11 September 2012 / Accepted: 11 December 2012 / Published online: 23 December 2012 Ó The Japanese Society of Nuclear Medicine 2012
Abstract Background We investigated long-term changes in aortic 18 F-fluorodeoxyglucose (18F-FDG) uptake and calcification in health-screening subjects and their relation with atherogenic risk factors. Methods and results A total of 94 consecutive subjects (72 men, 22 women; age 47–85 years, mean 57.9 years) participating in a health-screening protocol were evaluated retrospectively. All subjects had follow-up PET/CT scans 3.0–5.8 years (mean 4.1 years) later. We measured 18FFDG uptake (maximum SUV) and calcium score (Agatston score) of the ascending, descending thoracic and infrarenal abdominal aorta on PET/CT images. 18F-FDG uptake and calcium score of the whole aorta (FUWA and CSWA) increased significantly in the follow-up study compared with the initial study (p = 0.02 and p \ 0.0001, respectively).
Y. Ryu M. Nakadate H. Shibuya Department of Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan K. Yoshida (&) PET Imaging Center, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan e-mail: [email protected] Y. Suzuki Department of Internal Medicine, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan I. Umehara Department of Radiology, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan M. Tomita Clinical Research Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Multiple regression analysis showed that the change in FUWA per year was significantly associated with visceral fat area, while the change of CSWA per year was significantly associated with age and smoking habit. The degrees of 18FFDG uptake and calcium score increases were significantly greater in the abdominal aorta than in the thoracic aorta (p = 0.05 and p \ 0.0001, respectively). Conclusions Our data demonstrated the longitudinal progressions of vascular inflammation and calcification of health-screening subjects. Inflammation and calcification were observed to progress significantly faster in the abdominal aorta than in the thoracic aorta. The progressions of vascular inflammation and calcification may be associated with different atherogenic risk factors. Keywords Atherosclerosis Risk factors Vascular inflammation Vascular calcification Positron emission tomography
Introduction Atherosclerosis is a chronic inflammatory disorder that is associated with multiple risk factors. 18F-fluorodeoxyglucose (18F-FDG) PET imaging offers a noninvasive measure of vascular inflammation. Several cross-sectional studies have demonstrated a positive correlation between arterial 18 F-FDG uptake and atherogenic risk factors, such as age, visceral fat deposition
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