Long-term diet-induced, tissue-specific changes in (non)adipose triglyceride stores in obese patients with type 2 diabet
- PDF / 183,470 Bytes
- 1 Pages / 595.276 x 793.701 pts Page_size
- 10 Downloads / 178 Views
POSTER PRESENTATION
Open Access
Long-term diet-induced, tissue-specific changes in (non)adipose triglyceride stores in obese patients with type 2 diabetes mellitus Jacqueline T Jonker*, Marieke Snel, Sebastiaan Hammer, Arend E Meinders, Hanno Pijl, Ingrid M Jazet, Johannes A Romijn, Johannes WA Smit, Albert de Roos, Hildo J Lamb From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction A very low calorie diet (VLCD) induces considerable weight loss in patients with type 2 diabetes mellitus, associated with improved insulin sensitivity and decreased triglyceride (TG) stores in (non)adipose tissues. Long-term effects of a VLCD on tissue-specific TG accumulation, including pericardial fat, have not been documented. Purpose To assess the effects of a 16-week VLCD and of subsequent 14 months of follow-up on a regular diet on tissue-specific TG stores in obese type 2 diabetes patients. Methods We included 14 obese patients with insulin treated type 2 diabetes (mean±SEM: age 53±2 years; BMI 35±1 kg/ m2). (Non)adipose TG stores were measured using magnetic resonance (MR) imaging and MR proton spectroscopy before and after a 16-week VLCD (Modifast, 450 kcal/day) and after a 14-month follow-up without dietary interventions. Results A 16-week VLCD significantly reduced bodyweight, hepatic TG content, visceral and subcutaneous abdominal fat and pericardial fat volumes to 78, 16, 40, 55 and 83%, respectively, of baseline values (all p
Data Loading...
