Love wave based portable sensing system for on-line detection of carcinoembryonic antigen in exhaled breath condensate
- PDF / 623,668 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 57 Downloads / 201 Views
Love wave based portable sensing system for on-line detection of carcinoembryonic antigen in exhaled breath condensate Yingchang Zou 1
&
Yuan Zhou 1 & Ying Chen 1 & Xi Zhang 2 & Chunxue Ran 3
Accepted: 15 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Lung cancer is continuously the leading cause of cancer related death. Noninvasive exhaled breath condensate (EBC) detection using portable devices may pave a new avenue for monitoring conditions of the high-risk population of lung cancer, thereby increasing the 5-year survival rate. Here, a portable system is proposed for on-line detection of carcinoembryonic antigen (CEA) in EBC. This miniaturized system employs an aptameric Love-wave sensor to provide a detection with advantages of low cost, operational simplicity and high sensitivity. In addition, the aptasensor can be used in label-free and real-time monitoring. Integrating with measurement circuits and iOS APP, the system realizes online transmission and processing of signals which reflect the CEA concentration. Artificial samples have been detected, and experimental results demonstrate that the present system is sensitive (limit of detection = 1 ng/ml) and accurate (relative accuracy = 0.995). Applying in detection of clinical EBC, the relative error is as low as 0.305% and the result can be used to distinguish lung cancer patients from healthy subjects. Therefore, this portable system offers a potential solution for noninvasive detection of lung cancer in its early stage. Keywords Love-wave sensor . Aptamer . Lung cancer . Early detection . Exhaled breath condensate
1 Introduction Nowadays, cancer is becoming a major threat to human health. Among all cancers, lung cancer contributes the highest morbidity rate (11.6% of the total cases) and mortality rate (18.4% of the total cancer death) (Bray et al. 2018). Lung cancer screening programs are not yet available to a general population, so that lung cancer is often detected late when curative intervention is no longer possible [3]. Screening by the markers that are biologically related to tumor progression Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10544-020-00533-0) contains supplementary material, which is available to authorized users. * Yingchang Zou [email protected] 1
School of Electronic Information and Electrical Engineering, Changsha University, Changsha 410003, China
2
Biosensor National Special Lab, Key Lab for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
3
Zhejiang Sir Run Run Shaw Hospital, Department of Medicine, Zhejiang University, Hangzhou 310027, China
can probably provide even more mortality reduction by finding suspected patients as early as possible [7]. Carcinoembryonic antigen (CEA), a kind of glycoprotein found in colorectal carcinomas, has been widely recognized as one of the most important tumor markers for clinical application (Moertel et al.
Data Loading...
