Alendronic acid/ibandronic acid
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Femoral insufficiency fractures: 2 case reports Two women developed femoral insufficiency fractures associated with alendronic acid, or alendronic acid and ibandronic acid [indications not stated]. A 68-year-old woman was receiving oral alendronic acid 70mg once weekly for 3 years. She presented with a minimally displaced subtrochanteric fracture following a minor fall. She had been experiencing prodromal pain for 3 months, which had increased after the fall. X-ray revealed a widened lateral cortex in the subtrochanteric region and a transverse fracture line within the cortical thickening zone. She underwent an operation with intramedullary nailing, and postoperative healing was uneventful. A 73-year-old woman was initially receiving oral alendronic 70mg once weekly for 4 years, which was switched to IV ibandronic acid 3mg every 3 months for 2 years. She presented with a spontaneous diaphyseal fracture of the left femur. She had been experiencing prodromal thigh pain for 2 months. The fracture line was oblique, while a lateral cortex fracture was observed in an area of diffuse thickening and linear resorption that had been visible previously. She underwent an operation with intramedullary nailing, and postoperative healing was uneventful. Boszczyk A, et al. Femoral insufficiency fractures with bisphosphonate therapy. Cases study. Ortopedia Traumatologia Rehabilitacja 13: 403-8, No. 4, Jul-Aug 803070978 2011. Available from: URL: http://medsport.pl/en/ - Poland
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Reactions 26 May 2012 No. 1403
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