Luminescent metal organic frameworks with recognition sites for detection of hypochlorite through energy transfer
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ORIGINAL PAPER
Luminescent metal organic frameworks with recognition sites for detection of hypochlorite through energy transfer Lan Guo 1 & Yuan Liu 2 & Fengli Qu 1 & Zhe Liu 1 & Rongmei Kong 1 & Guang Chen 1 & Wenjing Fan 1 & Lian Xia 1 Received: 11 April 2019 / Accepted: 9 September 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2019
Abstract A luminescent metal organic framework (LMOF) of type UiO-66-NH2 was chosen for specific and sensitive detection of trace levels of hypochlorite. Hypochlorite causes the quenching of the blue fluorescence of nano-UiO-66-NH2 (with excitation/ emission maxima at 325/430 nm), and this finding forms the basis for a fluorometric assay for hypochlorite. The method overcomes disadvantages of conventional redox-probes which are interfered by oxidants with oxidation capability stronger than that of hypochlorite. Compared with other fluorescent probes for sensing hypochlorite, UiO-66-NH2 has a comparable detection limit of 0.3 μmol L−1 and a broad linearity relationship in the range of 1–8 μmol L−1. The probe was successfully applied to the detection of hypochlorite in complex water samples and living Hela cells. Keywords UiO-66-NH2 . Zr-based MOFs . Amino functionalized MOF . Non-redox mechanism . Fluorescence quenching . Porous materials . Water samples . DPD method
Introduction Hypochlorite (ClO−) and its protonated form of hypochlorous acid (HClO) are one kind of reactive oxygen species (ROS). They not only exist in water sources as bactericides and bleaching agents [1], but also exist in living system as endogenous hypochlorite [2]. Moreover, lots of studies have indicated that overexpression of hypochlorite can readily oxidize and chlorinate a series of biomolecules, such as nucleic acids, lipids and proteins. So they can lead to various diseases, tissue damages and even cancers [3, 4]. Therefore, to rigidly supervise water source safe and fully understand the physiological and pathological roles of hypochlorite, development highly Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-3806-x) contains supplementary material, which is available to authorized users. * Lian Xia [email protected] 1
Key Laboratory of Life-Organic Analysis of Shandong Province, Qufu Normal University, Qufu, Shandong 273165, People’s Republic of China
2
Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA
sensitive and selective methods for detecting hypochlorite are greatly important and necessary. Extensive efforts had been devoted to the development of organic fluorescent probes for detecting hypochlorite, such as coumarin, rhodamine, porphyrin, BODIPY and so on [5–10]. These small-molecule probes exhibit appealing advantage of high sensitivity and selectivity by functionalization of active groups. However, they intrinsically suffer fr
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