Lung Cancer Metastasis Novel Biological Mechanisms and Impact on Cli
Lung cancer is the leading cause of cancer related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer m
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Lung Cancer Metastasis Novel Biological Mechanisms and Impact on Clinical Practice
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Lung Cancer Metastasis
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Venkateshwar Keshamouni • Douglas Arenberg Gregory Kalemkerian, Editors
Lung Cancer Metastasis Novel Biological Mechanisms and Impact on Clinical Practice
Venkateshwar Keshamouni Douglas Arenberg Gregory Kalemkerian l
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Editors
Lung Cancer Metastasis Novel Biological Mechanisms and Impact on Clinical Practice
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Editors Venkateshwar G. Keshamouni Division of Pulmonary and Critical Care Medicine Department of Internal Medicine University of Michigan Health System 109 Zina Pitcher Place Ann Arbor MI 48109-2200 Biomedical Science Res. Bldg. USA [email protected]
Douglas A. Arenberg Division of Pulmonary and Critical Care Medicine University of Michigan Medical Center Department of Internal Medicine 1150 W. Medical Center Dr. 6301 MSRB III Ann Arbor, MI 48109–5642 [email protected]
Gregory P. Kalemkerian Division of Hematology/Oncology Department of Internal Medicine University of Michigan C350 MIB - SPF 5848 1500 E. Medical Center Drive Ann Arbor, MI 48109-5848 USA [email protected]
ISBN 978-1-4419-0771-4 e-ISBN 978-1-4419-0772-1 DOI 10.1007/978-1-4419-0772-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009933691 # Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer ScienceþBusiness Media (www.springer.com)
Preface
Lung cancer is the leading cause of cancer-related mortality, killing more than the combined tolls of breast, prostate, and colorectal cancers. In spite of this, the number of investigators studying this disease and the volume of funding devoted to lung cancer lag far behind these common solid tumors and other less lethal diseases. Metastatic lung cancer is responsible for more than 90% of lung cancerrelated deaths. However, relatively little progress has been made in understanding the process of metastasis. The two main aims of this book are (a) to introduce clinical concepts to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research and (b) to introduce new and emerging concepts and approaches in metastasis research to the lung cancer research community at large. To
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