Macronutrient intake and frailty: the Rotterdam Study
- PDF / 800,361 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 7 Downloads / 213 Views
ORIGINAL CONTRIBUTION
Macronutrient intake and frailty: the Rotterdam Study Eline Verspoor1,2 · Trudy Voortman1 · Frank J. A. van Rooij1 · Fernando Rivadeneira1,3 · Oscar H. Franco1,5 · Jessica C. Kiefte‑de Jong1,4 · Josje D. Schoufour1,3,6 Received: 19 June 2019 / Accepted: 29 October 2019 © The Author(s) 2019
Abstract Purpose To investigate the longitudinal association between the macronutrient composition of the diet and frailty. Methods Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related deficits, score between 0 and 100, and a higher score indicating more frailty. Frailty was assessed at baseline and 11 years later (range of 23 years). Macronutrient intake was assessed using food-frequency questionnaires. The association between macronutrients and frailty over time was evaluated using multivariable linear regression, adjusted for the frailty index at baseline, energy intake, and other relevant confounders. All analyses were performed in strata of BMI. Results Median frailty index score was 13.8 points (IQR 9.6; 19.1) at baseline and increased by a median of 2.3 points (IQR − 2.0; 7.6) after 11 years. Overall, we found no significant associations between intake of carbohydrates or fat and frailty over time. We did observe a significant positive association between an iso-energetic intake of 10 g protein and frailty over time (β 0.31 (95% CI 0.06; 0.55)) which was mainly driven by animal protein (β 0.31 (95% CI 0.07; 0.56)). It did not depend on whether it was substituted fat or carbohydrates. Conclusions Our findings suggest that a reduction in the intake of animal protein may improve the overall health status over time in a relatively healthy population. More research is needed on the optimal macronutrient composition of the diet and frailty in more vulnerable populations. Keywords Older adults · Frailty · Frailty index · Macronutrient intake
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00394-019-02131-0) contains supplementary material, which is available to authorized users. * Trudy Voortman [email protected] 1
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
2
Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
3
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
4
Department of Public Health and Primary Care, Leiden University Medical Center/LUMC Campus, The Hague, The Netherlands
5
Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland
6
Faculty of Sports and Nutrition, ACHIEVE‑Centre of Applied Research, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands
Introduction The rapid aging of our population is a major public health issue [1]. A longer lifespan is often accom
Data Loading...
