Magnesium sulfate
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Pulmonary oedema: case report A 33-year-old woman developed pulmonary oedema during treatment with magnesium sulfate for post-partum pre-eclampsia. The woman was admitted with acute hypoxaemic respiratory failure on day 7 after delivery. She developed dyspnoea 2 days post delivery, which worsened progressively. Physical examination showed tachypnoea, tachycardia and lower extremity pitting oedema. An electrocardiogram demonstrated sinus tachycardia with no ischaemic changes. Investigations including troponin, sputum cultures, influenza nucleic acid amplification and coxsackie titers returned negative. An echocardiogram demonstrated normal systolic function with no diastolic or valvular abnormalities. Chest x-ray showed bilateral interstitial oedema. A CTangiography of the chest revealed diffuse ground glass opacities with sub-pleural sparing, suggestive of pulmonary oedema with no evidence of pulmonary embolism. On further chart review, it was revealed that she received magnesium sulfate [dosage and route not stated] due to post-partum pre-eclampsia. It was revealed that along with a history of multiple gestation, magnesium sulfate was associated with the development of pulmonary oedema [duration of treatment to reaction onset not stated]. The woman was treated with unspecified diuretics, and was placed on non-invasive ventilation (NIV). One day later, she was weaned-off NIV. On hospital day 3, she was discharged [outcome not stated]. Afridi F, et al. Tocolytic induced pulmonary edema in a postpartum patient. American Journal of Respiratory and Critical Care Medicine 199: (plus poster) abstr. A1503, No. 803446302 9, May 2019. Available from: URL: https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A1503 [abstract]
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Reactions 18 Jan 2020 No. 1787
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