Malaria Immune Response to Infection and Vaccination
Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is
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aria
Immune Response to Infection and Vaccination
Malaria
Maria M. Mota • Ana Rodriguez Editors
Malaria Immune Response to Infection and Vaccination
Editors Maria M. Mota Instituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa Lisbon, Portugal
Ana Rodriguez Division of Parasitology Department of Microbiology New York University School of Medicine New York, NY, USA
ISBN 978-3-319-45208-1 ISBN 978-3-319-45210-4 (eBook) DOI 10.1007/978-3-319-45210-4 Library of Congress Control Number: 2016957986 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
Part I Immune Response to Infection Innate Immunity to Malaria........................................................................... Anton Götz, Maureen Ty, Angelo Ferreira Chora, Vanessa Zuzarte-Luís, Maria M. Mota, and Ana Rodriguez Mechanisms of Adaptive Immunity to Plasmodium Liver-Stage Infection: The Known and Unknown............................................................. Stina L. Urban, Katherine L. Doll, and John T. Harty
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Adaptive Immunity to Plasmodium Blood Stages......................................... Michelle N. Wykes, Robin Stephens, and Ian A. Cockburn
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Pathogenetic Immune Responses in Cerebral Malaria................................ Georges Emile Raymond Grau and Samuel Crocodile Wassmer
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A Role for Autoimmunity in the Immune Response Against Malaria........ Juan Rivera-Correa and Ana Rodriguez
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Part II Immune Response to Malaria Vaccines: Liver Stage Vaccines Whole-Sporozoite Malaria Vaccines.............................................................. António M. Mendes, Anja Scholzen, Ann-Kristin Mueller, Shahid M. Khan, Robert W. Sauerwein, and Miguel Prudêncio
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Immune
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