Male papillomavirus infection and genotyping in the Qingyuan area
- PDF / 815,402 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 26 Downloads / 178 Views
Open Access
RESEARCH
Male papillomavirus infection and genotyping in the Qingyuan area Wei‑Guo Yin1*†, Meng Yang1†, Lei Peng1, Yan‑Mei Liu1, Bin Cheng1, Shu‑Xia Xuan1, Chen Chen1 and Feng‑Jun Tan2
Abstract Background: This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide a reference basis for formulating prevention strategies for HPV infection. Methods: The present study collected urethral epithelium or scraped penile epidermis from high-risk male patients in Qingyuan People’s Hospital during the last five years, extracted DNA fragments using the boiling method, and detected 23 types of HPV genotypes by PCR-reverse blot hybridization. Results: The positive detection rate was 54.31% of 1044 males with high risk of HPV (567/1044). Among these males, the positive detection rate of HPV was the highest in patients initially diagnosed with warts, and the rate was 66.47%. Five main HPV types are identified as follows: HPV6 18.87% (197/1044), HPV11 10.25% (107/1044), HPV52 8.81% (92/1044), HPV16 6.90% (72/1044), and HPV51 5.08% (53/1044). Among these HPV-infected patients, single infection mainly by low-risk HPV6 and HPV11 accounted for 56.61% (321/567); high- and low-risk combined HPV co-infections accounted for 29.10% (165/567). The HPV infected patients was mainly between 21 and 40 years old, and the HPV infection rate was higher with increased age. Conclusions: The HPV infection rate in the Qingyuan area is higher than in other areas and the main infection is single infection. Furthermore, HPV52, HPV16, and HPV51 are the main high-risk infection types, while HPV6 and HPV11 are the main low-risk infection types. Keywords: Human papillomavirus, Genotype, Men, Qingyuan area, HPV infection Background Human papillomavirus (HPV) is a circular double-strand DNA virus belonging to Papillomaviridae family [1]. It has been reported that more than 100 types of HPV have been found. Among these, more than 40 species can infect the genitourinary tract. The International Agency for Research on Cancer (IARC) divides HPV into low-risk *Correspondence: [email protected] † Wei-Guo Yin and Meng Yang contributed equally to this work 1 Department of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, No. B24, Xincheng Yinquan Road, Qingcheng District, Qingyuan 511518, Guangdong, China Full list of author information is available at the end of the article
and high-risk types according to oncogenic potential risk. High-risk types can be integrated into the host genome. Repeated or persistent infection with high-risk HPV is a necessary condition and main risk factor for cervical cancer in women. The low-risk type is mainly correlated to genital warts [2]. It has been reported that male HPV infection significantly increases the risk of cervical cancer in their sexual partners [3]. Hence, the role of males in the occurrence and development of cervical cancer
Data Loading...
