Malignant Effusions Pleuritis, Ascites, Pericardites
Malignant effusions (pleurites, ascites and pericardites) are some of the most frequent manifestations of dissemination process of malignant tumors. Accumulation of the malignant fluid in serous cavities results in impairment of respiratory and cardiac fu
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Mikhail V. Kiselevsky Editor
Malignant Effusions Pleuritis, Ascites, Pericardites
Editor Mikhail V. Kiselevsky Russian Academy of Medical Science N.N. Blokhin Russian Cancer Research Center RAMS Laboratory of Cell Immunity 115478 Moscow, Russia
ISBN 978-94-007-4782-1 ISBN 978-94-007-4783-8 (eBook) DOI 10.1007/978-94-007-4783-8 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012948991 © Springer Science+Business Media Dordrecht 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Malignant effusions (pleural effusion, ascites and pericarditis) are some of the most frequent manifestations of dissemination process of malignant tumors. Accumulation of the malignant fluid in serous cavities results in impairment of respiratory and cardiac functions; however long lasting evacuation of the fluid leads to severe disorders of homeostasis that may directly cause the patient’s death. Although oncologic clinical practice has introduced various novel anti-cancer agents, the death rate of the patients with malignant effusions is still rather high. Mechanism of development of malignant effusions is mediated by a complex of factors, which lead to enhanced permeability of capillaries and decrease of lymphatic drainage of fluid due t
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