Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series
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REVIEW
Maternal and infant outcomes of full‑term pregnancy combined with COVID‑2019 in Wuhan, China: retrospective case series Yanfen Chen1 · Jun Bai2 Received: 28 March 2020 / Accepted: 26 April 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objective To investigate the maternal and infant outcomes of full-term pregnant patients in Wuhan, China, who were infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for coronavirus disease 2019 (COVID-2019). Design Retrospective case series. Setting The Central Hospitals of Wuhan, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China. Participants Twenty one full-term pregnant patients who were admitted to the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, confirmed SARS-CoV-2 infection and COVID-2019 with laboratorial and clinical methods, were reviewed by our medical team, and the data were collected from January 20, 2020 to February 29, 2020. Main clinical data collection Clinical data had been collecting using a standard case report form, such as epidemiological history, clinical manifestations, auxiliary examination of major laboratory and clinic, etc. All the information was collected and confirmed by our medical team. Results Twenty one full-term pregnant patients were reviewed (median age 29 years), and no patients were admitted to intensive care unit (ICU), and died during the treating progress. According to our review, all the cases were infected by human to human transmission, and the most common symptoms at onset of illness were cough in 17 (80.95%), fatigue in 10 (47.62%), fever in 7 (33.33%), expectoration in 1 (4.76%), and only one patient (4.76%) developed shortness of breath on admission. The median time from exposure to onset of illness was 10 days (interquartile range 7 –2 days), and from onset of symptoms to first hospital admission was 1 day (interquartile range 1–2 days). Conclusions As of February 29, 2020, all the patients who were full-term pregnancy combined with COVID-2019 were cured and delivered successfully, and all the newborns were not infected with SARS-CoV-2, and there were no evidence of mother-to-child transmission. Keywords Full-term pregnant patients · SARS-CoV-2 · COVID-2019
Introduction
* Jun Bai [email protected] 1
Department of Obstetrics, The Center Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, People’s Republic of China
Department of Obstetrics and Gynecology, The First People’s Hospital of Datong, 336 Hengan Avenue, Datong 037000, People’s Republic of China
2
In December 2019, a group of patients infected by SARSCoV-2 that is responsible for COVID-2019 in Wuhan, China. SARS-CoV-2 is similar to the coronavirus which was responsible for severe acute respiratory syndrome (SARS), and possess strong affinity to human respiratory receptors [1]. As of February 29, 2020, 48,577 COVID-2019 patients we
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