Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: a retrospective case series
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RESEARCH ARTICLE
Open Access
Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: a retrospective case series Tao Yao1,2†, Yan Gao1,2†, Qin Cui1,2†, Bo Peng1,2, Yan Chen1,2, Jiansheng Li1,2, Chao Huang1,3, Chunping He1,3, Jie Pu1,2, Jiajun Wei1,2, Yanqiang Zhan1,2, Jie Yan1,4, Jinghua Tian1,5, Zhaohui Zhang1,2* and Zhichao Liu1,2*
Abstract Background: With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and more death cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinical characteristics of deaths with COVID-19 pneumonia. Methods: We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia in East Hospital of Wuhan University Renmin Hospital, between January 26, 2020, and February 28, 2020. Results: Of the 83 deaths, none was the medical staff. The mean age was 71.8 years (SD 13.2; range, 34–97 years) and 53(63.9%) were male. The median from onset to admission was 10 days (IQR 7–14: range, 2–43 days), to death was 17 days (IQR 14–21: range, 6–54 days). Most deaths (66[80%]) had underlying comorbid diseases, the most of which was hypertension [47(57%)]. The main initial symptoms of these 83 deaths were shortness of breath(98.8%), fever(94%), and myalgia or fatigue(90.4%). Laboratory analyses showed the lymphocytopenia in 69(83%) deaths, hypoalbuminemia in 77(93%) deaths, the elevation of lactate dehydrogenase in 79(95%) deaths, procalcitonin in 69(83%) deaths and C-reactive protein in 79(95%) deaths. All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, 54(65.1%) deaths received glucocorticoid therapy, and 20(24.1%) patients received invasive mechanical ventilation. Conclusion: Most of the deaths with COVID-19 pneumonia were elderly patients with underlying comorbid diseases, especially those over 70 years of age. The time of death after the onset of the disease was mostly 15–21 days. More care should be given to the elderly in further prevention and control strategies of COVID-19. Keywords: Characteristics, COVID-19, Pneumonia, Death
* Correspondence: [email protected]; [email protected] † Tao Yao, Yan Gao and Qin Cui contributed equally to this work. 1 Union Department of Infection Disease, Wuhan University Renmin Hospital, Wuhan 430060, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material
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