Clinical characteristics of moderate and severe cases with COVID-19 in Wuhan, China: a retrospective study
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ORIGINAL ARTICLE
Clinical characteristics of moderate and severe cases with COVID‑19 in Wuhan, China: a retrospective study Lingshuang Sheng1 · Xiong Wang2 · Ning Tang2 · Fankai Meng1 · Liang Huang1 · Dengju Li1 Received: 5 May 2020 / Accepted: 11 September 2020 © Springer Nature Switzerland AG 2020
Abstract With the outbreak of COVID-19 ongoing, this infectious disease has been posing a significant threat to public health. However, we are still relatively inexperienced on recognizing the clinical characteristics of severe COVID-19 and death cases. Therefore, we hereby collected and analyzed a total of 232 cases to illustrate the clinical characteristics of such patients in Wuhan and to find notable marks for early clinical warning. We consider age, comorbidities, platelet count, albumin, D-dimer, LDH, CRP and IL-6 level might be more meaningful marks for COVID-19 prognostic evaluation. Keywords COVID-19 · SARS-cov-2 · Clinical characteristics
Introduction Coronavirus disease 2019 (COVID-19) is widely known as a type of severe infectious disease primarily transmitted via respiratory tract and body contact. It has demonstrated a series of clinical characteristics including long incubation period, strong infectivity, high occurrence of multiple organ dysfunction syndrome (MODS) and high mortality rate among severe cases. The infectious disease has been posing a significant threat to public health [1, 2]. On January 31, 2020, World Health Organization (WHO) officially announced COVID-19 as a public health emergency of international concern (PHEIC). As of July 2020, the COVID-19 pandemic has affected more than 200 countries and regions Article Summary Line At this time being, COVID-19 is one of the biggest research focus in the world. This manuscript collected a large number of severe and death cases with COVID-19 in Wuhan, China, which could provide more precise and potential indexes for prognostic evaluation and be useful for early warning and subsequent treatment decisions. * Dengju Li [email protected] 1
2
Department of Hematology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Hankou, Wuhan, Hubei, China Clinical Laboratory, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China
worldwide, with a total of more than 13 million confirmed cases and over 57,000 deaths [3]. The main clinical manifestations of COVID-19 are fever, dry cough and short of breath. Gastrointestinal symptoms and liver damage could also be observed in some cases [4, 5]. Severe patients might progress to dyspnea and even acute respiratory distress syndrome (ARDS), immunological derangement, coagulopathy, septic shock and MODS [6]. As a recent report showed that patients with COVID-19 could also develop the symptoms of anosmia and ageusia [7], we should also be alert for new clinical symptoms caused by the latent mutation of COVID-19 virus. During this study, we collected and analyzed a total of 232 cases f
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