Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis
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REVIEW ARTICLE
Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis Mohammad-Reza Sepand 1 & Mehdi Aliomrani 2 & Yazdan Hasani-Nourian 1 & Mohammad-Reza Khalhori 3 & Mohammad-Hosein Farzaei 3 & Nima Sanadgol 4,5 Received: 28 January 2020 / Accepted: 18 May 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Necroptosis is a regulated cell death that is governed by mixed lineage kinase domain-like, receptor-interacting serine-threonine kinase 3 and commonly displays with necrosis morphological characteristics. This study examined the molecular mechanisms involved in the chemical-induced necroptosis where a systematic evaluation of experimental studies addressing this issue is missing. We strictly reviewed all scientific reports related to our search terms including “necroptosis” or “programmed necrosis”, “environmental chemicals” or “air pollutants” or “pesticides” or “nanoparticles” and “Medicines” from 2009 to 2019. Manuscripts that met the objective of this study were included for further evaluations. Studies showed that several pathological contexts like cancer, neurodegenerative disorders, and inflammatory diseases were related to necroptosis. Furthermore, multiple chemical-induced cytotoxic effects, such as DNA damage, mitochondrial dysregulation, oxidative damage, lipid peroxidation, endoplasmic reticulum disruption, and inflammation are also associated with necroptosis. The main environmental exposures that are related to necroptosis are air pollutants (airborne particulate matter, cadmium, and hydrogen sulfide), nanoparticles (gold, silver, and silica), pesticides (endosulfan, cypermethrin, chlorpyrifos, and paraquat), and tobacco smoke. To sum up, air pollutants, pesticides, and nanoparticles could potentially affect human health via disruption of cell growth and induction of necroptosis. Understanding the exact molecular pathogenesis of these environmental chemicals needs further comprehensive research to provide innovative concepts for the prevention approaches and introduce novel targets for the amelioration of a range of human health problems. Keywords Apoptosis . Cell death . Environmental chemicals . Nanoparticles . Necroptosis
Highlights • Necroptosis can be triggered in response to the activation of multiple cell-surface receptors. • Abnormal and extreme activation of necroptosis may be concerned with cellular/tissue damage and ultimately lead to pathological abnormalities. • Air pollutants, pesticides, nanoparticles, and tobacco smoke could potentially mediate chemicals-induced necroptosis. • Cell type, exposure duration, and does play an essential role in chemicals-induced necroptosis. Responsible Editor: Lotfi Aleya * Nima Sanadgol [email protected]; [email protected] Mohammad-Reza Sepand [email protected] Mehdi Aliomrani [email protected] Yazdan Hasani-Nourian [email protected]
Mohammad-Reza Khalhori [email protected] Mohammad-Hosein Farzaei [email protected] Extended author information available on the last pa
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