Mechanotransduction of the Hair Cell
This book summarizes the emerging experimental evidence on hair-cell mechanotransduction, and covers hair’s cellular structure, biophysical properties, molecular components and functions. Auditory hair cells convert sound-induced vibration into electrical
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Wei Xiong Zhigang Xu
Mechanotransduction of the Hair Cell
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SpringerBriefs in Biochemistry and Molecular Biology
More information about this series at http://www.springer.com/series/10196
Wei Xiong • Zhigang Xu Editors
Mechanotransduction of the Hair Cell
Editors Wei Xiong School of Life Sciences, IDG/McGovern Institute for Brain Research Tsinghua University Beijing, China
Zhigang Xu School of Life Sciences Shandong University Jinan, Shandong, China
ISSN 2211-9353 ISSN 2211-9361 (electronic) SpringerBriefs in Biochemistry and Molecular Biology ISBN 978-981-10-8556-7 ISBN 978-981-10-8557-4 (eBook) https://doi.org/10.1007/978-981-10-8557-4 Library of Congress Control Number: 2018935907 © The Author(s) 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Acknowledgments
The authors are funded by the National Natural Science Foundation of China (31571080 and 31522025 to W. X.; 81771001 to Z. X.)
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Contents
1 A Brief Introduction.................................................................................... 1 Wei Xiong 2 Cellular Structure for Hair-Cell Mechanotransduction.......................... 5 Zhigang Xu 3 Biophysical Properties of Mechanotransduction...................................... 15 Wei Xiong 4 Molecular Components of Mechanotransduction Machinery................. 25 Zhigang Xu 5 Mechanotransduction and Inner Ear Function........................................ 49 Wei Xiong 6 Summary: Mechanotransduction and Beyond......................................... 59 Wei Xiong
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Chapter 1
A Brief Introduction Wei Xiong
Abstract Auditory perception in mammals starts from the ear, the per
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